Publications

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2010

Külzer, S., Rug, M., Brinkman, K., Cannon, P., Cowman, A., Lingelbach, K., Blatch, G.L., Maier, A.G., and Przyborski, J.M. 2010. Parasite encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum infected erythrocyte. Cell. Microbiol. (doi:10.1111/j.1462-5822.2010.01477.x).

Pesce, E.-R. , Cockburn, I.L., Goble, J.L., Stephens, L.L., and Blatch, G.L. 2010. Malaria heat shock proteins: Drug targets that chaperone other drug targets. Infect. Disord. Drug Targets. 10: 147-157.

Setati, M.M., Prinsloo, E., Longshaw, V. M., Murray, P.A., Edgar, D.H., and Blatch, G.L. 2010. Leukemia inhibitory factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells. IUBMB Life. 62: 61-66.

Goble, J.L., Adendorff, M.R., de Beer, T.A.P. Stephens, L.L., and Blatch, G.L. 2010. The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening. Protein Pept. Lett. 17: 109-120.

Louw, C.A., Ludewig, M.H., and Blatch, G.L. 2010. Overproduction, purification and characterisation of Tbj1, a novel Type III Hsp40 from Trypanosoma brucei, the African sleeping sickness parasite. Prot. Exp. Purif. 69: 168-177.

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2009

Lawson, J.C., Blatch, G.L., and Edkins, A.L. 2009. Cancer stem cells in breast cancer and metastasis. Breast Cancer Res. Treat. 118: 241-254.

Pesce, E.-R., and Blatch, G.L. 2009. The Hsp40-Hsp70 chaperone machinery of Plasmodium falciparum. AJBR. 3: 154-163.

Modisakeng, K.W., Jiwaji, M., Robert, J., Amemiya, C.T., Dorrington, R.A., and Blatch, G.L. 2009. Isolation of a Latimeria menadoensis heat shock protein 70 (Lmhsp70) that has all the features of an inducible gene and encodes a functional molecular chaperone. Mol. Genet. Genom. 282: 185-196.

Mutorwa, M., Salisu, S., Blatch, G.L., Kenyon, C., and Kaye, P.T. 2009. 3-Substituted aniline as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors. Synthetic Commun. 39: 2723-2736.

Longshaw, V.M., Stephens, L.L., Daniel, S., and Blatch, G.L. 2009. The TPR2B domain of the Hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization. Protein Pept. Lett. 16: 402-407.

Zimmermann, R., and Blatch, G.L. 2009. A novel twist to protein secretion in eukaryotes. Trends Parasitol. 25: 147-150.

Prinsloo, E, Setati, M.M., Longshaw V. and Blatch G.L. 2009. Chaperoning stem cells: a role for hear shock proteins in the regulation of embryonic stem cell self-renewal, maintenance and differentiation? BioEssays. 31:370-377.

Parfitt, D.A., Michael, G.J., Vermeulen, E., Prodromou, N.V., Webb, T.R., Gallo, J-M., Cheetham, M.E. Nicoll, W.S., Blatch, G.L., and Chapple, P. 2009. The ataxia protein sacsin is a functional cochaperone that that modifies the cellular fate of polyglutamine expanded ataxin-1. Hum. Mol. Genet. 18: 1556-1565.

Gentz, P.M., Blatch, G.L., and Dorrington, R.A. 2009. Dimerisation of the yeast eukaryotic translation initiation factor 5A requires hypusine and is RNA dependent. FEBS J. 276: 695-706.

Longshaw, V.M., Baxter, M., Prewitz, M., and Blatch, G.L. 2009. Knockdown of the co-chaperone Hop promotes extra-nuclear accumulation of STAT3 in mouse embryonic stem cells. Eur. J. Cell Biol. 88:153-166.

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2008

Birkholtz, L.-M., Blatch, G.L., Coetzer, T.L., Hoppe, H.C., Human, E., Morris, J.E., Ngcete, Z., Oldfield, L., Roth, R., Shonhai, A., Stephens L., and Louw, A.I. 2008. Heterologous expression of plasmodial proteins for structural studies and functional annotation. Malaria J. 7: 197 (doi:10.1186/1475-2875-7-197).

Pesce E.-R., Acharya P., Tatu U., Nicoll W. S., Shonhai A., Hoppe H. C., and Blatch, G.L. 2008. The Plasmodium falciparum heat shock protein 40, Pfj4, associates with heat shock protein 70 and shows similar heat induction and localisation patterns. Int. J. Biochem. Cell Biol. 40: 2914-2926.

Zimmermann, R., and Blatch G.L. 2008. Chaperones. In: Offermanns, S. and Rosenthal, W, eds. Encyclopedia of Molecular Pharmacology. Springer (ISBN: 978-3-540-38921-7).

Shonhai, A., Botha, M., de Beer, T.A.P., Boshoff, A., and Blatch, G.L. 2008. Structure-function study of a Plasmodium falciparum Hsp70 using three dimensional modelling and in vitro analyses. Protein and Peptide Letters. 15: 1117-1125.

Gordon AK, Blatch GL, Daniel S, Muller WJ. 2008. Stress protein responses in South African freshwater invertebrates exposed to detergent surfactant linear alkylbenzene sulfonate (LAS). Water Air Soil Pollut. 193: 123-130.

Daniel, S., Bradley, G., Longshaw, V., Söti, C., Csermely, P., and Blatch, G.L. 2008. Nuclear translocation of the phosphoprotein Hop (Hsp70/Hsp90 organizing protein) occurs under heat shock, and its proposed nuclear localization signal is involved in Hsp90 binding. BBA Mol Cell Res. 1783: 1003-1014.

Boshoff, A., Stephens, L.L., and Blatch G.L. 2008. The Agrobacterium tumefaciens DnaK: ATPase cycle, oligomeric state, and chaperone properties. Int. J. Biochem. Cell Biol. 40: 804-812.

For a complete list of Prof Gregory L Blatch's publications please click here