Names
Director of BioBRU:
Dr Adrienne Edkins
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Associated Academic Staff:
Dr Aileen Boshoff
Dr Earl Prinsloo
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Postdoctoral Researchers:
Dr Michael Ludewig
Characterization of trypanosomal Hsp40 proteins essential to growth and survival of the parasite
Dr Earl Prinsloo
Characterization of the molecular determinants of mouse STAT3 interaction with Hsp90
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Doctoral Students:
Jo-Anne de la Mare
Elucidation of the mechanisms of action of novel anti-cancer compounds on survival and proliferation of the MCF7 breast cancer cell line
Adelle Burger
Characterization of novel trypanosomal Hsp70 proteins
Nicodemus Mautsa
Structural and functional characterization of the protein inhibitor of activated STAT3 (PIAS3)
James Njung’e
Characterization of the Pfj1 and Hsp40-2 partner proteins of Plasmodium falciparum Hsp70
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Masters Students:
Lola Afolayan
Characterization of Pfj2, a P. falciparum Hsp40 chaperone potentially involved in ER protein quality control during the erythrocytic stages of the parasite lifecycle
Ingrid Cockburn
The effect of DSG and DSG analogues on the in vitro chaperone activity of PfHsp70-1
Leanne Cooper
Identifying the potential role of Hsp90 in differentiation and self-renewal pathways in the breast cancer (stem) cell model of MCF7 cells
Amy Kenyon
Extracellular Hsp90 and the modulation of integrins: a role in the motility of breast cancer cells?
Nana Maphumulo
Characterization of a Plasmodium falciparum type ll Hsp40 chaperone exported to the cytosol of infected erythrocytes
Ndumiso Mhlongo
Application of molecular chaperones to improve the heterologous production of Plasmodium falciparum protein adenosylmethionine decarboxylase
Buhle Moyo
Characterization of inhibitors of heat shock protein 90 (Hsp90) signalling in breast cancer cells and breast cancer stem cells
Jason Sterrenberg
Gene expression profiling for a molecular chaperone fingerprint in cancer stem cells
Tarryn Willmer
The role of Hsp90/Hsp70 organizing protein (Hop) in the proliferation, survival and invasion of cancer cells
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Honours Student:
Kabwela Chisaka, Kyle O’Hagan, Rowan Hatherley, Cindy Slater
