Rhodes University Logo
Rhodes > Chemistry > Staff > Academic Staff > Dr Setshaba D Khanye

Dr Setshaba D. Khanye

BSc, BSc Hons, MSc (Wits), PhD (UCT)

Headshot Dr Khanye

Lecturer in General Chemistry

Contact information

Tel: +27 46 603 8717; Fax: +27 46 62 25109

Postal Address: Department of Chemistry, Rhodes University, P O Box 94, Grahamstown, 6140, SOUTH AFRICA

Courier Address: Room F43 Department of Chemistry, Cnr of University and Artillery Roads, Rhodes University, Grahamstown, 6140, SOUTH AFRICA.

Email Address: s.khanye@ru.ac.za


  • Chemistry 1 – Electrochemistry, Inorganic and Environment Systems
  • Chemistry 2 – Inorganic Chemistry – Transition Metals Chemistry
  • Chemistry 3 – Bioinorganic and Organometallic Chemistry
  • Honours – Medicinal Chemistry
  •                - Physicochemical properties in drug design

Research Summary

The group research focus lies in the field of Bioinorganic and Medicinal Chemistry. The medicinal chemistry efforts are directed toward the causative agents of malaria, tuberculosis and trichomoniasis infections. The objective is to design target–directed inhibitors of molecular chaperons (i.e. Heat Shock Proteins), cysteine proteases, topoisomerase II/IV.

2017 Publications:

  1. Mbaba, M., Mabhula, A.N., Boel, N., Edkins, A.L., Isaacs, M., Hoppe, H.C. & Khanye, S.D. 2017. Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity. Journal of Inorganic Biochemistry, 172: 88–93. Available: http://dx.doi.org/10.1016/j.jinorgbio.2017.04.014
  2. Magwenzi, FN., Khanye, SD. And Veale, C., 2017. Unexpected transformations of 3-(bromoacetyl) coumarin provides new evidence for the mechanism of thiol mediated dehalogenation of α-halocarbonyls. Tetrahedron Letters. https://doi.org/10.1016/j.tetlet.2017.01.082
  3. Sekgota KC; Majumder S; Isaacs M; Mnkandhla D; Hoppe HC; Khanye SD; Kriel, FH; Coates J; Kaye PT ., 2017. Application of the Morita-Baylis-Hillman reaction in the synthesis of 3-[(N-cycloalkylbenzamido)methyl]-2-quinolones as potential HIV-1 integrase inhibitors. Bioorganic Chemistry. https://doi.org/10.1016/j.bioorg.2017.09.015

Representative Publications

Paper from Prof. Willem AL van Otterlo Laboratory (Wits University)

  1. Willem A.L. van Otterlo*, Garreth L. Morgans, Setshaba D. Khanye, Blessing A.A. Aderibigbe, Joseph P. Michael, David G. Billing, “Isomerization and ring-closing metathesis for the synthesis of 6-,7- and 8-membered benzo- and pyrido-fused N,N-, N,O- and N,S-heterocycles”, Tetrahedron Letters, 2004, 45, 9171-9175.
  2. Garreth L. Morgans, E. Lindani Ngidi, Lee G. Madeley, Setshaba D. Khanye, Joseph P. Michael, Charles B. de Koning, Willem A.L. van Otterlo*, “Synthesis of unsaturated 1,4-heretoatom-containing benzo-fused heterocycles using a sequential isomerisation-ring-closing metathesis strategy”, Tetrahedron, 2009, 65, 10650-10659.
  3. Abu Taher, Blessing A. Aderibigbe, Garreth L. Morgans, Lee G. Madeley, Setshaba D. Khanye, Leandi van der Westhuizen, Manuel A. Fernandes, Vincent J. Smith, Joseph P. Michael, Ivan R. Green, Willen A.L. van Otterlo*, “A ring-closing metathesis approach to eight-membered benzannelated scaffolds and subsequent internal alkene isomerizations”, Tetrahedron, 2013, 69, 2038-2047.

Papers from Dr Marcus Lay Laboratory (Wits University)

  1. Setshaba D. Khanye, Judy Caddy, Marcus Layh, “Gold(I) complexes of 1,2-bis(butylphenylphosphino)ethane and cis-1,2-bis(butylphenylphosphino)ethylene”,Gold Bulletin, 2007, 40, 45-51.
  2. Judy Caddy, E. Mabel Coyanis, Manuel A. Fernandes, Setshaba D. Khanye, Bernard Omondi, “Cis-ethylenebis(diphenylphosphine oxide)”, Acta Crystrallographica Section E, 2007, E63, o1387-o1389.
  3. Judy Caddy, E. Mabel Coyanis, Andreas Lemmerer, Setshaba D. Khanye, Bernardi Omondi, “Butlydiphenylphosphine oxide”, Acta Crystallographica Section E, 2007, E63, o1032-o1033.

Papers from Prof. Kelly Chibale and Gregory Smith Laboratory (University of Cape Town)

  1. Setshaba D. Khanye, Gregory S. Smith, Carmen Lategan, Peter J. Smith, Jiri Gut, Philip J. Rosenthal, Kelly Chibale, “Synthesis and in vitro evaluation of gold(I) thiosemicarbazone complexes for antimalarial activity”, Journal of Inorganic Biochemistry, 2010, 104, 1079-1083.
  2. Setshaba D. Khanye, Nikoletta B. Báthori, Gregory S. Smith, Kelly Chibale, “Gold(I) derived thiosemicarbazone complexes with rare halogen-halogen interaction – reduction of [Au(damp-C1,N)Cl2], Dalton Transactions, 2010, 39, 2697-2700.
  3. Setshaba D. Khanye, Jiri Gut, Philip J. Rosenthal, Kelly Chibale, Gregory S. Smith, “Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity”, Journal of Organometallic Chemistry, 2011, 696, 3296-3300.
  4. Setshaba D. Khanye, B. Wan, S.G. Franzblau, Jiri Gut, Philip J. Rosenthal, Gregory S. Smith, Kelly Chibale, “Synthesis and in vitro antimalarial and antitubercular activity of gold(III) complexes containing thiosemicarbazone ligands”, Journal of Organometallic Chemistry, 2011, 696, 3392-3396.

Last Modified: Tue, 13 Mar 2018 12:07:04 SAST