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Birth & Future of Multiscale Modeling of Macromolecules

Date: 20 November 2017 17:30 - 20 November 2017 18:30
Location: Zoology Major, Biological Sciences Building
Organiser: Charmaine Avery (Phone 046 603 8558)
Event Type: Alumni

Rhodes University and the Academy of Science of South Africa (ASSAf) cordially invite you to a Public Lecture on:

Birth & Future of Multiscale Modeling of Macromolecules by Prof Michael Levitt, ASSAf Distinguished Visiting Scholar

About Prof Michael Levitt

Born in South Africa in 1947, Prof Levitt was awarded the 2013 Nobel Prize for Chemistry (shared with Martin Karplus and Arieh Warshel). Prof Levitt’s diverse interests have included RNA & DNA modelling, protein folding simulation, classification of protein folds & protein geometry, antibody modelling, x-ray refinement, antibody humanisation, side-chain geometry, torsional normal mode,

molecular dynamics in solution, secondary structure prediction, aromatic hydrogen bonds, structure databases, and mass spectrometry. His current postdocs work on protein evolution, the crystallographic phase problem and Cryo-EM refinement. He has a passion in helping today’s young scientists gain the recognition and independence that his generation enjoyed.

Abstract

The development multiscale models for complex chemical systems began in 1967 with publications by Warshel and Levitt recently recognized by the 2013 Nobel Committee for Chemistry. The simplifications used then at the dawn of the age of computational structural biology were mandated by computers that were almost a billion times less cost effective than those we use today. These same multiscale models have become increasingly popular in application that range from simulation of atomic protein motion, to protein folding and explanation of enzyme catalysis. In this talk I describe the origins computational structural biology and then go on to show some of the most exciting current and future applications.

 

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