Dr. Abraham’s laboratory conducts research on the mechanisms of bacterial pathogenesis within the Department of Biochemistry and Microbiology. The research primarily focuses on elucidating the molecular mechanisms by which the intracellular bacterial pathogens Salmonella enterica and Mycobacterium tuberculosis interact with host cells to cause disease.
Many pathogenic bacteria have evolved mechanisms to facilitate their adherence and uptake into eukaryotic host cells. Within the intracellular environment, these pathogenic bacteria frequently modify or manipulate host cell functions and resources to promote their intracellular replication, survival and/or persistence. Several pathogenic bacterial species also capable of subverting host cell defences, thereby conferring these microbes with the ability to evade detection and elimination by host immune defence systems. The molecular mechanisms used by these bacteria to either adhere, enter, survive, replicate, and exit host cells is, however, only partially understood. The research in our laboratory is directed at studying the pathogenic interactions that occur between bacteria such as S. enterica and M. tuberculosis and their respective host cells.
2015- present:Rhodes University, Department of Biochemistry and Microbiology
2011-2014: University of Cape Town, Molecular Mycobacteriology Research Group and National Institutes of Health, Tuberculosis Research Section
2006-2010: University of Witwatersrand, Molecular Mycobacteriology Research Group
2002-2005: Friedrich-Alexander-Universität Erlangen-Nürnberg
Tel: +27 46 603 8779
Fax: +27 46 603 7576
Last Modified: Tue, 13 Nov 2018 14:49:22 SAST