Dr Jo-Anne de la Mare

JoLecturer in Biochemistry

Research Interests

  • Triple negative breast cancer cell biology
  • Drug discovery and medium-high throughput mechanistic analyses
  • Phenotypic screening of novel compounds

For detailed information on my research, please see the BioBRU website (link)

Academic Qualifications

PhD in Biochemistry (2012)

M.Sc in Microbiology with Distinction (2009)

B.Sc Hons. In Microbiology with Distinction (2006)

B.Sc in Microbiology and Biochemistry with Distinction (2005)

Positions and Awards

Senior Lecturer in Biochemistry (current)

Lecturer in Biochemistry (January 2017- 2019)

Claude Leon post-doctoral fellowship (2016)

Rhodes University post-doctoral fellowship (2015)

NRF Innovations post-doctoral fellowship (2012-2014)

NRF Prestigious PhD scholarship (2009-2011)

Publications

S. W. Odeyemi, J. De La Mare, A. L. Edkins and A.J. Afoloyan. (2019) In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum. Journal of Complementary and Integrative Medicine 16(3): 182-196. 

Larusha Gramni, Nyeleti Vukea,  Bheki Xulu, Abir Chakraborty, William John Samson, Laura Margaret Kirkpatrick Dingle, Jo-Anne de la Mare, Adrienne Edkins, Irvin Noel Booysen (2019). Anticancer evaluations of ruthenium (III) complexes with N-donor ligands tethered to coumarin or uracil moieties. Inorganica Chimica Acta. 492: 98-107 

Mziyanda Mbaba, Laura Dingle, Devon Cash, Dustin Laming, Jo-Anne de la Mare, Dale Taylor, Heinrich C. Hoppe, Adrienne L. Edkins, Setshaba D. Khanye (2020). Ferrocenyl 1,3-benzoxazines as bioactive agents: Repurposing a polymer precursor for pharmaceutical application. European Journal of Medicinal Chemistry 187. https://doi.org/10.1016/j.ejmech.2019.111924 02

Mziyanda Mbaba, Jo-Anne de la Mare, Jason N. Sterrenberg, Adrienne L. Edkins, Michelle Isaacs, Heinrich C. Hoppe, Setshaba D. Khanye (2019). Ferrocenyl novobiocin derivatives with in vitro anticancer and antimalarial activities. Journal of Inorganic Biochemistry 24(2): p 139–149.

Michael G. Knott, Jo-Anne de la Mare, Adrienne L. Edkins, Angel Zhang, Martin J. Stillman, John J. Bolton, Edith M. Antunes, and Denzil R. Beukes (2019). Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum. Phytochemistry Letters.29:182-185

W. Odeyemi, J. De La Mare, A. L. Edkins and A.J. Afoloyan. (2019) In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum. Journal of Complementary and Integrative Medicine. Doi: 10.1515/jcim-2018-0184.

Larusha Gramni, Nyeleti Vukea, Bheki Xulu, Abir Chakraborty, William John Samson, Laura Margaret Kirkpatrick Dingle, Jo-Anne de la Mare, Adrienne Edkins, Irvin Noel Booysen (2019). Anticancer evaluations of ruthenium (III) complexes with N-donor ligands tethered to coumarin or uracil moieties. Inorganica Chimica Acta. 492: 98-107

Cindy Slater,  Jo-Anne de la Mare  and  Adrienne Lesley Edkins (2018). In vitro analysis of putative cancer stem cell populations  and chemosensitivity in the SW480 and SW620  colon cancer metastasis model. Oncology Letters 15(6):8516-8526. doi: 10.3892/ol

Gunjan Mandal, Subir Biswas, Sougata Roy Chowdhury, Annesha Chatterjee, Suman Purohit, Poulomi Khamaru, Sayan Chakraborty, Palash Kumar Mandal, Arnab Gupta, Jo-Anne de la Mare, Adrienne Lesley Edkins, Arindam Bhattacharyya (2018). Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression. Biochim Biophys Acta (Molecular Basis of Disease) 1864(6 Pt A):2053-2066.

Jo-Anne de la Mare, Tamarin Perks and Adrienne L. Edkins (2017). Extracellular Hsp90 and TGF? regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. Cancer Cell International.

Godwin Akpeko Dziwornu, Mino Caira, Jo-Anne de la Mare, Adrienne Edkins, John Bolton, Denzil Beukes, Suthananda Sunassee (2017). Isolation, characterization and cytotoxicity of new metabolites from the South African endemic red algal species Laurencia alfredensis. Molecules 22: 513

Clinton G.L. Veale, Adrienne L. Edkins,  Jo-Anne de la Mare, Carmen de Kock, Peter J. Smith  and Setshaba D. Khanye (2015). Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable electrophilic intermediate. Tetrahedron Letters 56(14):1860-1864

Saeb Aliwaini, Wendy L Kröger, Angelique Blanckenberg, Jo-Anne de la Mare, Adrienne L Edkins, Selwyn Mapolie and Sharon Prince(2015). The palladacycle AJ-5 exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells. Cancer Letters. 357(1):206-18

Jo-Anne de la Mare, Lara Contu, Morgan C Hunter, Buhle Moyo, Lorraine Z Mutsvunguma, Jason N Sterrenberg, Karim Dhanani and Adrienne L Edkins (2014). Breast cancer: current developments in molecular approaches to diagnosis and treatment. Recent Patents in Anti-Cancer Drug Discovery 9(2): 153-175.

Gwynneth Felicity Matcher, Meesbah Jiwaji, Jo-Anne de la Mare and Rosemary Ann Dorrington (2013). Complex pathways for regulation of pyrimidine metabolism by carbon catabolite repression and quorum sensing in Pseudomonas putida RU-KM3S. Applied Microbiology and Biotechnology. 97:5993–6007

Jo-Anne de la Mare, Jason N. Sterrenberg, Mugdha G. Sukhthankar, Maynard T. Chiwakata, Denzil R. Beukes, Gregory L. Blatch and Adrienne L. Edkins (2013). Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay. Cancer Cell International 13:39-54.

Candice L. Bromley, Shirley Parker-Nance, Jo-Anne de la Mare, Adrienne L. Edkins, Denzil R. Beukes and Michael T. Davies-Coleman (2013). New oxindole from the South African marine ascidian Distaplia skoogi. South African Journal of Chemistry 66:64–68.

Suthananda N Sunassee, Clinton G Veale, Nelusha Shunmoogam-Gounden, Omalaja Osoniyi, Denver T Hendricks, Mino R Caira, Jo-Anne de la Mare, Adrienne L Edkins, Antônio V Pinto, Eufrânio N da Silva Júnior and Michael T Davies-Coleman (2013). Cytotoxicity of lapachol, ?-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells. European Journal of Medicinal Chemistry 62:98-110.

Jo-Anne de la Mare, Jessica C Lawson, Maynard T Chiwakata, Denzil R Beukes, Adrienne L Edkins and Gregory L Blatch (2012). Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitroInvestigational New Drugs 30:2187- 2200.

Book Chapter

Earl Prinsloo, Leanne C. Cooper, Buhle Moyo, Jo-Anne de la Mare, Jessica C. Lawson Adrienne Edkins, and Gregory L Blatch. Heat Shock Proteins in Normal and Cancer Stem Cell Biology: Implications for Regenerative and Chemotherapeutic Medicine IN Stem Cells, Regenerative Medicine and Cancer (©2010 Nova Science Publishers, Inc.). Editor: Shree Ram Singh, Chapter 27, pp.693-713. ISBN: 978-1-61761-342-5.

Contact Information

Telephone: +27-46-603-7332

e-mail: j.delamare@ru.ac.za

Location: Rm 254, 2nd floor of Biological Sciences Building, Cnr Artillery and Prince Alfred rd

 

Last Modified: Mon, 27 Jan 2020 09:30:14 SAST