Lecturer in Biochemistry Research Interests

• Triple negative breast cancer cell biology
• Drug discovery and medium-high throughput mechanistic analyses
• Phenotypic screening of novel compounds
• Establishment of cervical cancer cell lines from patient biopsies

Academic Qualifications

PhD in Biochemistry (2012)

M.Sc in Microbiology with Distinction (2009)

B.Sc Hons. In Microbiology with Distinction (2006)

B.Sc in Microbiology and Biochemistry with Distinction (2005)

Positions and Awards

Head of Biochemistry (current)

Senior Lecturer in Biochemistry (current)

Vice-president of the South African Society for Biochemistry and Molecular biology (current)

Secretary of the South African Society for Biochemistry and Molecular biology (2018-2021)

Lecturer in Biochemistry (January 2017- 2019)

Claude Leon post-doctoral fellowship (2016)

NRF Innovations post-doctoral fellowship (2012-2014)

Recent publications

Serah Kimani, Suparna Chakraborty, Ikponmwosa Irene, Jo de la Mare, Adrienne Edkins, Andr ́e du Toit, Ben Loos, Angelique Blanckenberg, Annick Van Niekerk, Leticia V. Costa-Lotufo, KN ArulJothi, Selwyn Mapolie, Sharon Prince. (2021) The palladacycle, BTC2, exhibits anti-breast cancer and breast cancer stem cell activity. Biochemical Pharmacology 190: 114598

Douglas Kemboi Magozwi, Xolani Peter, Moses K. Langat, Richwell Mhlanga, Nyeleti Vukea, Jo-Anne de la Mare, Xavier Siwe-Noundou, Rui W.M. Krause, Vuyelwa Jacqueline Tembu. In vitro cytotoxic effects of chemical constituents of Euphorbia grandicornis Blanc against breast cancer cells (2021). Scientific African doi: https://doi.org/10.1016/j.sciaf.2021.e01002

Mziyanda Mbaba, Laura MK Dingle, Ayanda I Zulu, Dustin Laming, Tarryn Swart, Jo-Anne de la Mare, Heinrich C Hoppe, Adrienne L Edkins, Setshaba D Khanye (2021). Coumarin-Annulated Ferrocenyl 1,3-Oxazine Derivatives Possessing In Vitro Antimalarial and Antitrypanosomal Potency. Molecules 26(5):1333

Mziyanda Mbaba; Laura M.K. Dingle; Tarryn Swart; Devon Cash; Dustin Laming; Jo-Anne de la Mare; Dale Taylor; Heinrich C. Hoppe; Christophe Biot, Adrienne L. Edkins; Setshaba D. Khanye (2020). The in vitro antiplasmodial and antiproliferative activity of new ferrocene-based α-aminocresols targeting hemozoin inhibition and DNA interaction.  ChemBioChem DOI:cbic.202000132 

Sanam Maikoo, Abir Chakraborty, Nyeleti Vukea, Laura Margaret Kirkpatrick Dingle, William John Samson, Jo-Anne de la Mare, Adrienne Lesley Edkins & Irvin Noel Booysen (2020). Ruthenium complexes with mono- or bis-heterocyclic chelates: DNA/BSA binding,antioxidant and anticancer studies, Journal of Biomolecular Structure and Dynamics, DOI: 10.1080/07391102.2020.1775126 

Zecarias W. Teclegeorgish, Ntebogeng S. Mokgalaka, Vukea N, de la Mare, JA,  Tembu, VJ. (2020). Cytotoxicity of triterpenoids from Clerodendrum glabrum against triple negative breast cancer cells in vitro. South African Journal of Botany 133:144-150. 

Samantha Joy Beckley, Morgan Campbell Hunter, Sarah Naulikha Kituyi, Ianthe Wingate, Abantika Chakraborty, Kelly Schwarz, Matodzi Portia Makhubu, Robert Pierre Rousseau, Duncan Kyle Ruck, Jo-Anne de la Mare, Gregory Lloyd Blatch, Adrienne Lesley Edkins (2020) STIP1/HOP regulates the actin cytoskeleton through interactions with actin and changes in actin binding proteins cofilin and profilin. International Journal of Molecular Sciences 21, 3152; doi:10.3390/ijms21093152 

S. W. Odeyemi, J. De La Mare, A. L. Edkins and A.J. Afoloyan. (2019) In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum. Journal of Complementary and Integrative Medicine 16(3): 182-196. 

Larusha Gramni, Nyeleti Vukea,  Bheki Xulu, Abir Chakraborty, William John Samson, Laura Margaret Kirkpatrick Dingle, Jo-Anne de la Mare, Adrienne Edkins, Irvin Noel Booysen (2019). Anticancer evaluations of ruthenium (III) complexes with N-donor ligands tethered to coumarin or uracil moieties. Inorganica Chimica Acta. 492: 98-107 

Mziyanda Mbaba, Laura Dingle, Devon Cash, Dustin Laming, Jo-Anne de la Mare, Dale Taylor, Heinrich C. Hoppe, Adrienne L. Edkins, Setshaba D. Khanye (2020). Ferrocenyl 1,3-benzoxazines as bioactive agents: Repurposing a polymer precursor for pharmaceutical application. European Journal of Medicinal Chemistry 187. https://doi.org/10.1016/j.ejmech.2019.111924 02

Mziyanda Mbaba, Jo-Anne de la Mare, Jason N. Sterrenberg, Adrienne L. Edkins, Michelle Isaacs, Heinrich C. Hoppe, Setshaba D. Khanye (2019). Ferrocenyl novobiocin derivatives with in vitro anticancer and antimalarial activities. Journal of Inorganic Biochemistry 24(2): p 139–149.

Michael G. Knott, Jo-Anne de la Mare, Adrienne L. Edkins, Angel Zhang, Martin J. Stillman, John J. Bolton, Edith M. Antunes, and Denzil R. Beukes (2019). Plaxenone A and B: Cytotoxic halogenated monoterpenes from the South African red seaweed Plocamium maxillosum. Phytochemistry Letters.29:182-185

W. Odeyemi, J. De La Mare, A. L. Edkins and A.J. Afoloyan. (2019) In vitro and in vivo toxicity assessment of biologically synthesized silver nanoparticles from Elaeodendron croceum. Journal of Complementary and Integrative Medicine. Doi: 10.1515/jcim-2018-0184.

Larusha Gramni, Nyeleti Vukea, Bheki Xulu, Abir Chakraborty, William John Samson, Laura Margaret Kirkpatrick Dingle, Jo-Anne de la Mare, Adrienne Edkins, Irvin Noel Booysen (2019). Anticancer evaluations of ruthenium (III) complexes with N-donor ligands tethered to coumarin or uracil moieties. Inorganica Chimica Acta. 492: 98-107

Cindy Slater, Jo-Anne de la Mare  and  Adrienne Lesley Edkins (2018). In vitro analysis of putative cancer stem cell populations  and chemosensitivity in the SW480 and SW620  colon cancer metastasis model. Oncology Letters 15(6):8516-8526. doi: 10.3892/ol

Contact Information

Telephone: +27-46-603-7332

e-mail: j.delamare@ru.ac.za

Location: Rm 235, 2^nd floor of Biological Sciences Building, Cnr Artillery and Prince Alfred rd

Last Modified: Mon, 19 Feb 2024 11:43:37 SAST