Mr P Makoni

Qualifications

BPharm(Rhodes), MSc(Rhodes)

Designation

Senior Lecturer (Pharmacology)

Room no: 407 Telephone: 0466038780 Email: p.makoni@ru.ac.za

Teaching

Pharmacokinetics and Pharmacodynamics of drugs

Autonomic drugs

Antihypertensives, antiarrhythmics and antianginal drugs

Drugs for the management of congestive heart failure

Antihyperlipidaemics

Anticoagulants, antiplatelets and fibrinolytics

Anti-anaemic drugs

Drugs for the hypothalamic and anterior pituitary hormones - analogues and their inhibitors

Drugs for the thyroid disorders: Thyroid hormones- analogues and their inhibitors

Drugs for the hypothalamic, pituitary disorders: Hormones regulating plasma calcium level- Parathormone, calcitonin and Vitamin-D

Oestrogens, progestogens and contraceptives. Androgens and anabolic steroids. Hormone replacement therapy

Drugs acting on the uterus: oxytocics and tocolytics. Infertility drugs and urologicals

Gastrointestinal system drugs

Complementary and alternative medicines

Toxicology: Clinical toxicology

Management of hypertension

Research

Formulation, development, and delivery of poorly soluble drugs using lipid nanocarriers (SLN, NLC).

Selected Publications

  1. Witika, B.A.; Makoni, P.A.; Mweetwa, L.L.; Ntemi, P.V.; Chikukwa, M.T.R.; Matafwali, S.K.; Mwila, C.; Mudenda, S.; Katandula, J.;Walker, R.B. Nano-Biomimetic Drug Delivery Vehicles: Potential Approaches for Covid-19 Treatment. Molecules. 2020
  2. Makoni, P.A.; Khamanga, S.M.; Walker, R.B. Muco-adhesive Clarithromycin-Loaded Nanostructured Lipid Carriers for Ocular Delivery: Formulation, Characterization, Cytotoxicity and Stability. J Drug DelivSci Technol. https://doi.org/10.1016/j.jddst.2020.102171
  3. Witika, B.A.; Makoni, P.A.; Matafwali, S.K.; Chabalenge, B.; Mwila, C.; Kalungia, A.C.; Nkanga, C.I.; Bapolisi, A.M.; Walker, R.B. Biocompatibility of Biomaterials for Nanoencapsulation: Current Approaches. Nanomaterials. 2020, 10, 1649
  4. Makoni, P.A.; Wa Kasongo, K.; Walker, R.B. Preformulation studies of efavirenz with lipid excipients using thermal and spectroscopic techniques. Pharmazie 2020, 75, 417-423
  5. Makoni, P.A.; Ranchhod, J.; WaKasongo, K.; Khamanga, S.M.; Walker, R.B. The use of quantitative analysis and Hansen solubility parameter predictions for the selection of excipients for lipid nanocarriers to be loaded with water soluble and insoluble compounds. Saudi Pharm. J. 2020, 28, 305–315
  6. Makoni, P.A.; Chikukwa, M.T.R.; Khamanga, S.M.; Walker, R.B. Stability Indicating HPLC-ECD Method for the Analysis of Clarithromycin in Pharmaceutical Dosage Forms: Method Scaling versus Re-Validation. Sci. Pharm. 2019, 87, 31
  7. Makoni, P.A.; Kasongo, K.W.; Walker, R.B. Short Term Stability Testing of Efavirenz-Loaded Solid Lipid Nanoparticle (SLN) and Nanostructured Lipid Carrier (NLC) Dispersions. Pharm. 2019, 11, 397
  8. Makoni, P.A.; Khamanga, S.M.; Wa Kasongo, K.; Walker, R.B. The use of experimental design for the development and validation of an HPLC-ECD method for the quantitation of efavirenz. Pharmazie 2018, 73, 570–578

Web presence

LinkedIn: www.linkedin.com/in/pedzisai-makoni-33a806a9

Professional affiliations

Registered with South African Pharmacy Council

Hobbies and interests

Working out and watching sport

Last Modified: Thu, 28 Jan 2021 04:22:38 SAST