Sorted by year:

BioBRU publications numbered in each year - most recent first. BioBRU members or alumni are underlined. 

Total Peer-Reviewed Publications = 108



  1. Gregory L. Blatch, Adrienne L. Edkins, John T. Price and A. Graham Pockley (Editors).        Heat shock proteins as modulators and therapeutic targets of chronic disease: an            integrated perspective. Philosophical Transactions of the Royal Society B. 2018. Volume      372, Issue 1735, 5 December, ISSN: 0962-8436
  2. Boel N.M.E., Hunter M.C., Edkins AL. LRP1 is required for novobiocin-mediated                  fibronectin turnover. 2018. Scientific Reports 8: 11438.  018-29531-2
  3. Mandal G, Biswas S, Chowdhury SR, Chatterjee A, Purohit S, Khamaru P, Chakraborty S, Mandal PK, Gupta A, de la Mare J-A, Edkins AL*, Bhattacharyya A. Heterodimer formation by Oct4 and Smad3 differentially regulates epithelial-to-mesenchymal transition-associated factors in breast cancer progression. 2018. BBA-Molecular Basis of Disease. 1864 (6), 2053-2066.
  4. Edkins AL*, Price JT, Pockley AG, Blatch GL. Heat shock proteins as modulators and therapeutic targets of chronic disease: an integrated perspective. Philosophical Transactions of the Royal Society B. 2018. 373 (1738). Published online Dec 4 2017 DOI:10.1098/rstb.2016.0521
  5. Boel N and Edkins AL*. (2018) Regulation of the Extracellular Matrix by Heat Shock Proteins and Molecular Chaperones. Chapter in “Heat Shock Proteins in the Immune System”. pp 97-121. Editors: P Srivastava and RJ Binder. Springer ISBN 978-3-319-69042-1.
  6. Slater, C., de la Mare J-A., Edkins, AL*. In vitro analysis of putative cancer stem cell populations and chemosensitivity in the SW480 and SW620 colon cancer metastasis model. 2018 Oncology Letters. Published online 4th April 2018 DOI: 10.3892/ol.2018.8431
  7. CGL Veale, B Mehari, S Kituyi, S Chaudhary, S Combrinck, W Chen, M Isaacs, H Hoppe, Edkins AL, A Viljoen. NMR structural elucidation of channaine, an unusual alkaloid from Sceletium tortuosum. Phytochemistry Letters. 2018 23, 189-193
  8. Mayibongwe J. Lunga, Ruramai L. Chaisango, Carli Weyers, Michelle Isaacs, Dale Taylor, Edkins AL, Setshaba D. Khanye, Heinrich Hoppe, Clinton G. L. Veale. Expanding the SAR of non-toxic antimalarial indolyl-3-ethanone ethers and thioethers. 2018 Chem Med Chem. 10.1002/cmdc.201800235


  1. Dhanani KCH, Samson WJ, Edkins AL*. Fibronectin is a stress responsive gene regulated by HSF1 in response to geldanamycin. Scientific Reports 2017 7 (1), 17617. DOI:10.1038/s41598-017-18061-y
  2. De la Mare J-A, Perks T, Edkins AL*. Extracellular Hsp90 and TGF? regulate adhesion, migration and anchorage independent growth in a paired colon cancer cell line model. BMC Cancer. 2017. 17 (1), 202. 10.1186/s12885-017-3190-z.
  3. Mbaba M, Mabhula A, Boel N, Edkins AL, Isaacs M, Hoppe H, Khanye S. Ferrocenyl and organic novobiocin derivatives: Synthesis and their in vitro biological activity. Journal of Inorganic Biochemistry 2017. 172, 88-93
  4. GA. Dziwornu, MR. Caira, J-A de la Mare, AL. Edkins, JJ. Bolton, DR. Beukes, SN. Sunassee. Isolation, characterization and cytotoxicity of new metabolites from the South African endemic red algal species Laurencia alfredensis. Molecules 2017. 22 (4), 513. DOI 10.3390/molecules22040513


  1. Mattison SA, Blatch GL and Edkins AL*. HOP expression is regulated by p53 and RAS and characteristic of a cancer gene signature. Cell Stress and Chaperones. 2016 Published online, p1-11 DOI: 10.1007/s12192-016-0755-8.
  2. Chiwakata M, de la Mare JA, Edkins A, Beukes DR. Sarqaquinoic acid and related synthetic naphthoquinones inhibit the function of Hsp90. Planta Med. 2016 Dec;81(S 01):S1-S381. DOI: 10.1055/s-0036-1596751
  3. Olsen,EK, de Cerf CK, Dziwornu GA, Puccinelli E, Ansorge I, Samaai T, Dingle LMK, Edkins AL, Sunassee SN. (2016) Cytotoxic activity of marine sponge extracts from the sub–Antarctic islands and the Southern Ocean. SAJS 112 (11/12) Art. #2016-0202, 5 pages.
  4. Faridoon, AL. Edkins, M Isaacs, D Mnkandhla, HC. Hoppe, PT. Kaye. Synthesis and Evaluation of Substituted 4-(N-Benzylamino)cinnamate Esters as Potential Anti-Cancer Agents and HIV-1 Integrase Inhibitors. Bioorganic & Medicinal Chemistry Letters 2016 Aug 1;26(15):3810-2. doi: 10.1016/j.bmcl.2016.05.023
  5. Edited book: Heat Shock Protein Inhibitors. Topics in Medicinal Chemistry. 2016 Editors: Shelli McAlpine and Adrienne Edkins. Springer. ISBN: 978-3-319-32605-4
  6. Edkins AL*. (2016). Hsp90 Co-chaperones as Drug Targets in Cancer: Current Perspectives. Chapter in “Heat Shock Protein Inhibitors: Success Stories” for the series Topics in Medicinal Chemistry pp 21-54. Editor: Shelli McAlpine and Adrienne Edkins. Springer. ISBN: 978-3-319-32605-4


  1. Edkins AL*. (2015) CHIP: A Co-chaperone for Degradation by the Proteasome. Subcellular Biochemistry.78:219-42. doi: 10.1007/978-3-319-11731-7_11.
  2. Baindur-Hudson S, Edkins AL*, Blatch GL. (2015) Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins. Subcellular Biochemistry.78:69-90. doi: 10.1007/978-3-319-11731-7_3.
  3. S Aliwaini, WL. Kröger, A Blanckenberg, Jo de la Mare, AL Edkins, S Mapolie, S Prince. The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells. Cancer Letters 2015; 357: 206–218, doi:10.1016/j.canlet.2014.11.027
  4. C Veale, AL Edkins, J-A de la Mare, C de Kock, PJ Smith, SD Khanye. Facile synthesis and biological evaluation of assorted indolyl-3-amides and esters from a single, stable carbonyl nitrile intermediate. Tetrahedron Letters 2015; 56:1860-1864, doi:10.1016/j.tetlet.2015.02.090
  5. AH Kramer, CL Frost, AL Edkins, HC Hoppe, E. Prinsloo. Dynamic mitochondrial localisation of STAT3 in the cellular adipogenesis Model 3T3-L1. Journal of Cellular Biochemistry 2015 Jul;116(7):1232-40. doi: 10.1002/jcb.25076
  6. Pesce ER, Blatch GL and Edkins AL*. (2015). Hsp40 as drug targets: towards the Development of Specific Inhibitors. Chapter in “Heat Shock Protein Inhibitors: Success Stories” for the series Topics in Medicinal Chemistry. pp 163-195. Editors: Shelli McAlpine and Adrienne Edkins. Springer. ISBN: 978-3-319-32605-4
  7. Edkins AL*. (2015) CHIP: A Co-chaperone for Degradation by the Proteasome. Chapter in “Networking of chaperones by co-chaperones”. Second edition. Editors: Adrienne Edkins and Greg Blatch; available online as: Subcellular Biochemistry.78:219-42. doi: 10.1007/978-3-319-11731-7_11.
  8. Baindur-Hudson S, Edkins AL*, Blatch GL. (2015) Hsp70/Hsp90 organising protein (hop): beyond interactions with chaperones and prion proteins. Chapter in “Networking of chaperones by co-chaperones”. Second edition. Editors: Adrienne Edkins and Greg Blatch; available online as Subcellular Biochemistry.78:69-90. doi: 10.1007/978-3-319-11731-7_3.



  1. Pesce ER, Blatch GL and Edkins AL. (2014). Hsp40 as drug targets: current state of the field. Chapter in “Heat Shock Protein Inhibitors: Success Stories” for the series Topics in Medicinal Chemistry. Editor: Shelli McAlpine. Springer. In press
  2. Edkins AL and Boshoff A. (2014) General structural and functional features of heat shock proteins. Book Chapter in: Heat shock proteins of malaria. Editors: Addmore Shonhai and Greg Blatch. Springer, ISBN 978-94-007-7437-7; pp5 -45
  3. Kramer, A. H., Joos-Vandewalle, J., Edkins, A. L., Frost, C. L., & Prinsloo, E. 2014. Real-time monitoring of 3T3-L1 preadipocyte differentiation using a commercially available electric cell-substrate impedance sensor system. Biochemical and biophysical research communications, 1–6. doi:10.1016/j.bbrc.2013.12.123.
  4. Hunter M.C., O’ Hagan K.L., Kenyon A., Dhanani K.C.H., Prinsloo E.A., Edkins A.L. 2014. Hsp90 Binds Directly to Fibronectin (FN) and Inhibition Reduces the Extracellular Fibronectin Matrix in Breast Cancer Cells. PLoS ONE 9(1): e86842. doi:10.1371/journal.pone.0086842.
  5. de la Mare JA, Contu L, Hunter MC, Moyo B, Sterrenberg JN, Dhanani KCH, Mutsvunguma LZ and Edkins AL. 2014. Breast Cancer: Current developments in molecular approaches to diagnosis and treatment. Recent Patents on Anti-Cancer Drug Discovery. 9(2): 153-175.
  6. Kadye, R., Kramer, A. H., Joos-Vandewalle, J., Parsons, M., Njengele, Z., Hoppe, H., & Prinsloo, E. 2014. Guardian of the Furnace: Mitochondria, TRAP1, ROS and stem cell maintenance. IUBMB life, (21), 1–4. doi:10.1002/iub.1234.
  7. Cockburn, I.L., Boshoff, A., Pesce, E.R. and Blatch, G.L. 2014. Selective modulation of plasmodial Hsp70s by small molecules with antimalarial activity. Biol Chem. Epub. doi: 10.1515/hsz-2014-0138.
  8. Burger, A., Ludewig, M.H. and Boshoff, A. 2014. Investigating the Chaperone Properties of a Novel Heat Shock Protein, Hsp70.c, from Trypanosom brucei. 2014. Journal of Parisitology Research. Volume 2014, 172582. doi: 10.1155/2014/172582.
  9. Edited Book: Networking of chaperones by co-chaperones. Second Edition. 2014. Editors: Adrienne Edkins and Greg Blatch. Published by Springer. In press.


  1. Willmer, T., Contu, L., Blatch, G.L. and Edkins, A.L.2013. Knockdown of Hop downregulates RhoC expression, and decreases pseudopodia formation and migration in cancer cell lines. Cancer Letters. 328(2): 252-260.Candice L. Bromley, Shirley Parker-Nance, Jo-Anne de la Mare, Adrienne L. Edkins, Denzil R. Beukes and Michael T. Davies-Coleman. 2013. Halogenated oxindole and indoles from the South African marine ascidian Distaplia skoogi. South African Journal of Chemistry 66:64–68.
  2. de la Mare JA, Sterrenberg JN, Sukhthankar MG, Chiwakata MT, Beukes DR, Blatch GL and Edkins AL. 2013. Assessment of potential anti-cancer stem cell activity of marine algal compounds using an in vitro mammosphere assay. Cancer Cell International 13 (1), 39.
  3. Suthananda N Sunassee, Clinton G Veale, Nelusha Shunmoogam-Gounden, Omalaja Osoniyi, Denver T Hendricks, Mino R Caira, Jo-Anne de la Mare, Adrienne L Edkins, Antônio V Pinto, Eufrânio N da Silva Júnior and Michael T Davies-Coleman. 2013. Cytotoxicity of lapachol, ?-lapachone and related synthetic 1,4-naphthoquinones against oesophageal cancer cells. European Journal of Medicinal Chemistry 62:98-110.
  4. Tastan-Bishop, O., Edkins, A.L. and Blatch, G.L. 2013. Sequence and domain conservation of the coelacanth Hsp40 and Hsp90 chaperones suggests conservation of function. Journal of Experimental Zoology. 09/2013. doi: 10.1002/jezb.22541.
  5. Amemiya, C.T....Blatch, G.L....Edkins, A.L....Lindblad-Toh, K. 2013. The African coelacanth genome provides insights to tetrapod evolution. 2013. Nature. 496 (7445): 311-316.
  6. Njunge, J.M., Ludewig, M.H., Boshoff, A., Pesce, E.R. and Blatch, G.L. 2013. Hsp70s and J proteins of Plasmodium parasites infecting rodents and primates: structure, function, clinical relevance, and drug targets. Curr Pharm Des. 19(3): 387-403.
  7. Goble, J.L., Johnson, H., de Ridder, J., Stephens, L.L., Louw, A., Blatch, G.L. and Boshoff, A. 2013. The druggable antimalarial target PfDXR: overproduction strategies and kinetic characterisation. Protein Pept Lett. 20(2): 115-124.


  1. Jo-Anne de la Mare, Jessica C Lawson, Maynard T Chiwakata, Denzil R Beukes, Adrienne L Edkins and Gregory L Blatch. 2012. Quinones and halogenated monoterpenes of algal origin show anti-proliferative effects against breast cancer cells in vitro.  Investigational New Drugs 30:2187- 2200. 
  2. Prinsloo, E., Kramer, A. H., Edkins, A. L., & Blatch, G. L. 2012. STAT3 interacts directly with Hsp90. IUBMB life. 64(3): 266-273.  doi:10.1002/iub.607.
  3. Edkins AL, Borland G, Kelley, SM, Cogdell R, Ozanne B, Cushley W.  Analysis of the CD23-alphaV integrin interaction; a study with model peptides. Biochem Biophys Res Commun. 2012 Jun 1;422(2):207-12.
  4. Edkins AL, Borland G, Acharya M, Cogdell R, Ozanne B, Cushley W. Differential regulation of monocyte cytokine release by ?v and ?2 integrins that bind CD23. Immunology 2012 Jun;136(2):241-51. DOI: 10.1111/j.1365-2567.2012.03576.x.
  5. Edkins AL and Blatch GL.(2012) Targeting conserved pathways as a strategy for novel drug development: disabling the cellular stress response. Book Chapter in: Drug Discovery in Africa. Editor:  Kelly Chibale. ISBN 978-3-642-28175-4.
  6. Sennuga, A., van Marwijk, J., Boshoff, A. and Whiteley, C.G. 2012. Enhanced activity of chaperonin GroEL in the presence of platinum nanoparticles. Journal of Nanoparticle Research. 14:824.


  1. Sterrenberg J.N, Blatch G.L and Edkins A.L. 2011. Human DNAJ in cancer and stem cells. Cancer Letters 312 (2), 129 – 142.  
  2. Mutsvunguma LZ, Moetlhoa, B, Edkins AL, Luke GA, Blatch GL, Knox, C. 2011. Theiler’s murine encephalomyelitis virus infection induces a redistribution of heat shock proteins 70 and 90 in BHK-21 cells, and is inhibited by novobiocin and geldanamycin. Cell Stress and Chaperones 16:505–515.
  3. Mautsa, N., Prinsloo, E., Bishop, O.T. and Blatch, G.L. 2011. The PINIT domain of PIAS3: structure-funciton analysis of its interaction with STAT3. Journal of Molecular Recognition. 24(5): 795-803.
  4. Burger, A., Whiteley, C. And Boshoff, A. 2011. Current prospective of the Escherichia coli RNA degraadosome. Biotechnology Letters. 33(12): 2337-2350.


  1. Acharya M, Borland G, Edkins AL, Maclellan LM, Matheson J, Ozanne BW, Cushley W. CD23/Fc?RII: molecular multi-tasking. Clin Exp Immunol. 2010 Oct;162(1):12-23. DOI: 10.1111/j.1365-2249.2010.04210.x.
  2. Earl Prinsloo, Leanne C. Cooper, Buhle Moyo, Jo-Anne de la Mare, Jessica C. Lawson Adrienne Edkins, and Gregory L Blatch. 2010. Heat Shock Proteins in Normal and Cancer Stem Cell Biology: Implications for Regenerative and Chemotherapeutic Medicine IN Stem Cells, Regenerative Medicine and Cancer (©2010 Nova Science Publishers, Inc.). Editor: Shree Ram Singh, Chapter 27, pp.693-713. ISBN: 978-1-61761-342-5.
  3. Cooper, L.C., Prinsloo, E., Edkins, A.L. and Blatch, G.L.2010. Hsp90?/? associates with the GSK3?/axin1/phospho-?-catenin complex in the human MCF-7 epithelial breast cancer model. Biochemical and Biophysical Research Communications. 413(4): 550-554.
  4. Jauka TI, Mutsvuguma L, Boshoff A, Edkins AL, Knox C. 2010. Localisation of Theiler’s Murine Encephalomyelitis virus protein 2C to the Golgi apparatus using antibodies generated against a peptide region. J Virol Methods 168:162–169.
  5. Külzer, S., Rug, M., Brinkman, K., Cannon, P., Cowman, A., Lingelbach, K., Blatch, G.L., Maier, A.G., and Przyborski, J.M. 2010. Parasite encoded Hsp40 proteins define novel mobile structures in the cytosol of the P. falciparum infected erythrocyte. Cell. Microbiol. (doi:10.1111/j.1462-5822.2010.01477.x).
  6. Pesce, E.-R. , Cockburn, I.L., Goble, J.L., Stephens, L.L., and Blatch, G.L. 2010. Malaria heat shock proteins: Drug targets that chaperone other drug targets. Infect. Disord. Drug Targets. 10: 147-157.
  7. Setati, M.M., Prinsloo, E., Longshaw, V. M., Murray, P.A., Edgar, D.H., and Blatch, G.L. 2010. Leukemia inhibitory factor promotes Hsp90 association with STAT3 in mouse embryonic stem cells. IUBMB Life. 62: 61-66.
  8. Goble, J.L., Adendorff, M.R., de Beer, T.A.P. Stephens, L.L., and Blatch, G.L. 2010. The malarial drug target Plasmodium falciparum 1-deoxy-D-xylulose-5-phosphate reductoisomerase (PfDXR): development of a 3-D model for identification of novel, structural and functional features and for inhibitor screening. Protein Pept. Lett. 17: 109-120.
  9. Louw, C.A., Ludewig, M.H., and Blatch, G.L. 2010. Overproduction, purification and characterisation of Tbj1, a novel Type III Hsp40 from Trypanosoma brucei, the African sleeping sickness parasite. Prot. Exp. Purif. 69: 168-177.


  1. Lawson, J.C., Blatch, G.L., and Edkins, A.L. 2009. Cancer stem cells in breast cancer and metastasis. Breast Cancer Res. Treat. 118: 241-254.
  2. Modisakeng, K.W., Jiwaji, M., Robert, J., Amemiya, C.T., Dorrington, R.A., and Blatch, G.L. 2009. Isolation of a Latimeria menadoensis heat shock protein 70 (Lmhsp70) that has all the features of an inducible gene and encodes a functional molecular chaperone. Mol. Genet. Genom. 282: 185-196.
  3. Mutorwa, M., Salisu, S., Blatch, G.L., Kenyon, C., and Kaye, P.T. 2009. 3-Substituted aniline as scaffolds for the construction of glutamine synthetase and DXP-reductoisomerase inhibitors. Synthetic Commun. 39: 2723-2736.
  4. Pesce, E.-R., and Blatch, G.L. 2009. The Hsp40-Hsp70 chaperone machinery of Plasmodium falciparum. AJBR. 3: 154-163.
  5. Longshaw, V.M., Stephens, L.L., Daniel, S., and Blatch, G.L. 2009. The TPR2B domain of the Hsp70/Hsp90 organizing protein (Hop) may contribute towards its dimerization. Protein Pept. Lett. 16: 402-407.
  6. Zimmermann, R., and Blatch, G.L. 2009. A novel twist to protein secretion in eukaryotes. Trends Parasitol. 25: 147-150.
  7. Prinsloo, E.A.G., Setati, M.M., and Blatch G.L. 2009. Chaperoning stem cells: a role for hear shock proteins in the regulation of embryonic stem cell self-renewal, maintenance and differentiation? BioEssays. 31:370-377.
  8. Parfitt, D.A., Michael, G.J., Vermeulen, E., Prodromou, N.V., Webb, T.R., Gallo, J-M., Cheetham, M.E. Nicoll, W.S., Blatch, G.L., and Chapple, P. 2009. The ataxia protein sacsin is a functional cochaperone that that modifies the cellular fate of polyglutamine expanded ataxin-1. Hum. Mol. Genet. 18: 1556-1565.
  9. Longshaw, V.M., Baxter, M., Prewitz, M., and Blatch, G.L. 2009. Knockdown of the co-chaperone Hop promotes extra-nuclear accumulation of STAT3 in mouse embryonic stem cells. Eur. J. Cell Biol. 88:153-166.
  10. Gentz, P.M., Blatch, G.L., and Dorrington, R.A. 2009. Dimerisation of the yeast eukaryotic translation initiation factor 5A requires hypusine and is RNA dependent. FEBS J. 276: 695-706.
  11. Prinsloo, E., Setati, M.M., Longshaw, V.M. and Blatch, G.L. 2009. Chaperoning stem cells: a role for heat shock proteins in the modulation of stem cell self-renewal and differentiation? Bioessays. 31 (4): 370-377.
  12. Acharya M, Edkins AL, Ozanne BW, Cushley W. SDF-1 and PDGF enhance alphavbeta5-mediated ERK activation and adhesion-independent growth of human pre-B cell lines. Leukemia. 2009 Oct;23(10):1807-17.


  1. Birkholtz, L.-M., Blatch, G.L., Coetzer, T.L., Hoppe, H.C., Human, E., Morris, J.E., Ngcete, Z., Oldfield, L., Roth, R., Shonhai, A., Stephens L., and Louw, A.I. 2008. Heterologous expression of plasmodial proteins for structural studies and functional annotation. Malaria J. 7: 197 (doi:10.1186/1475-2875-7-197).
  2. Pesce E.-R., Acharya P., Tatu U., Nicoll W. S., Shonhai A., Hoppe H. C., and Blatch, G.L. 2008. The Plasmodium falciparum heat shock protein 40, Pfj4, associates with heat shock protein 70 and shows similar heat induction and localisation patterns. Int. J. Biochem. Cell Biol. 40: 2914-2926.
  3. Zimmermann, R., and Blatch G.L. 2008. Chaperones. In: Offermanns, S. and Rosenthal, W, eds. Encyclopedia of Molecular Pharmacology. Springer (ISBN: 978-3-540-38921-7).
  4. Shonhai, A., Botha, M., de Beer, T.A.P., Boshoff, A., and Blatch, G.L. 2008. Structure-function study of a Plasmodium falciparum Hsp70 using three dimensional modelling and in vitro analyses. Protein and Peptide Letters. 15: 1117-1125.
  5. Gordon AK, Blatch GL, Daniel S, Muller WJ. 2008. Stress protein responses in South African freshwater invertebrates exposed to detergent surfactant linear alkylbenzene sulfonate (LAS). Water Air Soil Pollut. 193: 123-130.
  6. Daniel, S., Bradley, G., Longshaw, V., Söti, C., Csermely, P., and Blatch, G.L. 2008. Nuclear translocation of the phosphoprotein Hop (Hsp70/Hsp90 organizing protein) occurs under heat shock, and its proposed nuclear localization signal is involved in Hsp90 binding. BBA Mol Cell Res. 1783: 1003-1014.
  7. Boshoff, A., Stephens, L.L., and Blatch G.L. 2008. The Agrobacterium tumefaciens DnaK: ATPase cycle, oligomeric state, and chaperone properties. Int. J. Biochem. Cell Biol. 40: 804-812.
  8. Shonhai, A., Botha, M., de Beer, T.A.P., Boshoff, A. and Blatch, G.L. 2008. Structure-function study of a Plasmodium falciparum Hsp70 using three dimensional modelling and in vitro analyses. Protein and Peptide Letters. 15(10): 1117-1125.


  1. Botha, M., Pesce, E.-R., and Blatch G.L. 2007. The Hsp40 proteins of Plasmodium falciparum and other apicomplexa: regulating chaperone power in the parasite and the host. Int. J. Biochem. Cell Biol. 39: 1781-1803.
  2. Shonhai, A., Boshoff, A., and Blatch, G.L. 2007. The structural and functional diversity of Hsp70 proteins from Plasmodium falciparum. Protein Science. 16: 1803-1818.
  3. Nicoll, W.S., Botha, M., McNamara, C., Schlange, M., Pesce, E., Boshoff, A., Ludewig, M.H., Zimmermann, R., Cheetham, M.E., Chapple, J.P., and Blatch, G.L. 2007. Cytosolic and ER J-domains of mammalian and parasite origin can interact with DnaK. Int. J. Biochem. Cell Biol. 39: 736-751.
  4. Csermely, P., Söti, C., and Blatch, G.L. 2007. Chaperones as parts of cellular networks. In: Csermely, P. and Vígh L., eds. Molecular aspects of the stress response: chaperones, membranes and networks, Advances in Experimental Medicine and Biology vol. 594. Austin: Landes Bioscience; New York: Springer Science+Business Media, 55-63 (publication date 27-11-06; ISBN: 0-387-39974-7).
  5. Daniel, S., Söti, C., Csermely, P., Bradley, G., and Blatch, G.L. 2007. Hop: an Hsp70/90co-chaperone that functions within and beyond Hsp70-Hsp90 protein folding pathways. In: Blatch G.L., ed. Networking of Chaperones by Co-Chaperones. Austin: Landes Bioscience; New York: Springer Science + Business Media, 26-37 (publication date 04-12-06; ISBN: 978-0-387-49308-4).
  6. Edited book: Networking of chaperones by co-chaperones. First Edition. 2007. Editors: Greg Blatch. Published by Springer. ISBN 978-0-387-49308-4
  7. Borland G, Edkins AL, Acharya M, Matheson J, White LJ, Allen JM, Bonnefoy JY, Ozanne BW, Cushley W. alphavbeta5 integrin sustains growth of human pre-B cells through an RGD-independent interaction with a basic domain of the CD23 protein. J Biol Chem. 2007 Sep 14;282(37):27315-26.


  1. Modisakeng, K.W., Amemiya, C.T., Dorrington, R.A., and Blatch, G.L. 2006. Molecular Biology studies on the coelacanth: a review. Special Coelacanth Issue of S. Afr. J. Sci. 102: 479-485.
  2. Longshaw, V.M., Nicoll, W.S., Botha, M., Ludewig, M.H., Shonhai, A., Stephens, L.L., and Blatch G.L. 2006. Getting practical with molecular chaperones. Biotechnology International. 18: 24-27.
  3. Nicoll, W.S., Boshoff, A., Ludewig, M.H., Hennessy, F., Jung, M., and Blatch, G.L. 2006. Approaches to the isolation and characterization of molecular chaperones. Prot. Exp. Purif. 46: 1-15.
  4. Sinclair, B.J., Terblanche, J.S., Scott, M.B., Blatch, G.L., Klok, J., and Chown, S.L. 2006. Environmental physiology of three species of collembola at Cape Hallett, North Victoria Land, Antarctica. Journal of Insect Physiology. 52: 29-52.
  5. Shonhai, S., Boshoff, A., and Blatch, G.L. 2005. Plasmodium falciparum heat shock protein 70 is able to suppress the thermosensitivity of an Escherichia coli DnaK mutant strain. Mol Genet Genom. 274: 70-78.


  1. Hennessy, F., Nicoll, W.S., Zimmermann, R., Cheetham, M.E., and Blatch, G.L. 2005. Not all J domains are created equal: implications for the specificity of Hsp40-Hsp70 interactions. Protein Science. 14: 1697-1709.
  2. Hennessy, F., Boshoff, A., and Blatch, G.L. 2005. Rational mutagenesis of the J domain identifies residues critical to the in vivo function of the Agrobacterium tumefaciens DnaJ. Int. J. Biochem. Cell Biol. 37: 177-191.
  3. Shonhai, A., Boshoff, A. and Blatch, G.L. 2005. Plasmodium falciparum heat shock protein 70 is able to suppress the thermosensitivity of an Escherichia coli DnaK mutant strain. Molecular and General Genetics. 274(1): 70-78.
  4. Edkins A, Murray V. Management of chemically contaminated bodies. J R Soc Med. 2005 Apr;98(4):141-5. [IF:1.366]


  1. Modisakeng, K.W., Dorrington, R.A., Blatch, G.L. 2004. Isolation of genes encoding heat shock protein 70 (hsp70s) from the coelacanth, Latimeria chalumnae. Special Rhodes University Centenary Issue of S. Afr. J. Sci. 100: 683-686.
  2. Limson, J., Odunuga, O.O., Green, H., Höök, F., and Blatch G.L. 2004. The use of Quartz Crystal Microbalance with Dissipation (QCM-D) for the measurement of protein-protein interactions: a qualitative and quantitative analysis of the interactions between molecular chaperones. Special Rhodes University Centenary Issue of S. Afr. J. Sci. 100: 678-682.
  3. Boshoff, A., Nicoll, W.S., Hennessy, F., Ludewig, M.H., Daniel, S., Modisakeng, K.W., Shonhai, A., McNamara, C., Bradley, G., and Blatch. G.L. 2004. Molecular chaperones in biology, medicine and protein biotechnology. Special Rhodes University Centenary Issue of S. Afr. J. Sci. 100: 665-677.
  4. Boshoff, A., Hennessy, F., and Blatch, G.L. 2004. The in vivo and in vitro characterization of DnaK from Agrobacterium tumefaciens RUOR. Prot. Exp. Purif. 38: 161-169.
  5. Odunuga, O.O., Longshaw, V.M., and Blatch, G.L. 2004. Hop: more than an Hsp70/Hsp90 adaptor protein. BioEssays. 26: 1058-1068.
  6. Edkins, A.L., Ludewig, M.H., and Blatch G.L. 2004. A Trypanosoma cruzi heat shock protein 40 is able to stimulate the adenosine triphosphate hydrolysis activity of heat shock protein 70 and can substitute for a yeast heat shock protein 40. Int. J. Biochem. Cell Biol. 36: 1585-1598.
  7. Longshaw, V.M., Chapple, J.P., Balda, M.S., Cheetham, M.E. and Blatch, G.L. 2004. The nuclear translocation of the Hsp70/Hsp90 organizing protein mSTI1 is regulated by cell cycle kinases. J. Cell Sci. 117:701-710
  8. Matambo, T.S., Odunuga, O.O., Boshoff, A., and Blatch, G.L. 2004. Over-production, purification and characterization of the Plasmodium falciparum heat shock protein 70. Prot.Exp.Purif. 33: 214-222


  1. Odunuga, O.O., Hornby, J.A., Bies, C., Zimmerman, R., Pugh, D.J. and Blatch, G.L. 2003. Tetratricopeptide repeat motif-mediated Hsc70-mSTI1 interaction: molecular characterization of the critical contacts for successful binding and specificity. J. Biol. Chem. 278: 6896-6904.



  1. Edkins AL (2013) Cancer: not an African problem? Science in Africa. Published online health/cancer-not-african-problem.
  2. Edkins A and Cushley W. (2012) The Jekyll and Hyde nature of antibodies. Biological Sciences Review. Phillip Alan magazines for Hodder education.
  3. Edkins, AL (2008) Public Engagement with Science Oral Presentation on Biotechnology in Medical Research at the South African Agency for Science and Technology Advancement (SAASTA) Public Understanding of Biotechnology (PUB) Media Round Table, 15 October 2008, Cape Town, RSA. Also broadcast on internet at

Last Modified: Thu, 21 Nov 2019 11:40:59 SAST