Microbiology lecturer

 

Research interests

Dr Ledwaba’s research interests include One Health-related water quality and hygiene aspects, bacterial pathogenesis mechanisms, antimicrobial resistance and the transmission pathways of infectious pathogens.

 

Brief biography

Lecturer in Microbiology (2023-current)

Post-doctoral fellow, Department of Biochemistry and Microbiology, University of Venda, SA (2020-2022)

PhD in Microbiology, University of Venda, SA (2020)

Pre-doctoral research, Division of Infectious Diseases and International Health, University of Virginia, USA (2016-2018)

MSc in Microbiology, University of Venda, SA (2015)

BSc in Microbiology, University of Limpopo, SA (2013)

 

Recent publications

Potgieter N, Heine L, Ngandu JP, Ledwaba SE, Zitha T, Mudau LS, Becker P, Traore AN, Barnard TG. 2023. High Burden of Co-Infection with Multiple Enteric Pathogens in Children Suffering with Diarrhoea from Rural and Peri-Urban Communities in South Africa. Pathogens.12(2):315.

Rikhotso MC, Ledwaba SE, Ngandu JP, Mavumengwana V, Kinnear CJ, Warren R, Potgieter N, Traoré AN. 2023. Favourable outcomes in RR-TB patients using BPaL and other WHO-recommended second-line anti-TB drugs. The International Journal of Tuberculosis and Lung Disease. 27(8):599-605.

Ledwaba SE, Bolick DT, de Medeiros PH, Kolling GL, Traore AN, Potgieter N, Nataro JP, Guerrant RL. 2022. Enteropathogenic Escherichia coli (EPEC) expressing a non-functional bundle-forming pili (BFP) also leads to increased growth failure and intestinal inflammation in C57BL/6 mice. Brazilian Journal of Microbiology. 53(4):1781-7.

Costa DV, Moura-Neto V, Bolick DT, Guerrant RL, Fawad JA, Shin JH, Medeiros PH, Ledwaba SE, Kolling GL, Martins CS, Venkataraman V. 2021. S100B inhibition attenuates intestinal damage and diarrhea severity during Costridioides difficile infection by modulating inflammatory response. Frontiers in Cellular and Infection Microbiology. 11:739874.

Ledwaba SE, Costa DV, Bolick DT, Giallourou N, Medeiros PH, Swann JR, Traore AN, Potgieter N, Nataro JP, Guerrant RL. 2020. Enteropathogenic Escherichia coli infection induces diarrhea, intestinal damage, metabolic alterations, and increased intestinal permeability in a murine model. Frontiers in Cellular and Infection Microbiology. 10:595266.

Medeiros PH, Bolick DT, Ledwaba SE, Kolling GL, Costa DV, Oriá RB, Lima AÂ, Barry EM, Guerrant RL. 2020. A bivalent vaccine confers immunogenicity and protection against Shigella flexneri and Enterotoxigenic Escherichia coli infections in mice. npj Vaccines. 27;5(1):30.

Ledwaba SE, Becker P, Traore-Hoffman A, Potgieter N. 2019. Bacterial contamination of children’s toys in rural Day care centres and households in South Africa. International Journal of Environmental Research and Public Health.16(16):2900.

QS Medeiros PH, Ledwaba SE, Bolick DT, Giallourou N, Yum LK, Costa DV, Oriá RB, Barry EM, Swann JR, Lima AÂ, Agaisse H. 2019.  A murine model of diarrhea, growth impairment and metabolic disturbances with Shigella flexneri infection and the role of zinc deficiency. Gut Microbes. 10(5):615-30.

Bolick DT, Medeiros PH, Ledwaba SE, Lima AA, Nataro JP, Barry EM, Guerrant RL. 2018. Critical role of zinc in a new murine model of Enterotoxigenic Escherichia coli diarrhea. Infection and Immunity. 86(7):10-128.

Giallourou N, Medlock GL, Bolick DT, Medeiros PH, Ledwaba SE, Kolling GL, Tung K, Guerry P, Swann JR, Guerrant RL. 2018. A novel mouse model of Campylobacter jejuni enteropathy and diarrhea. PLoS Pathogens. 14(3):e1007083.

Ledwaba SE, Kabue JP, Barnard TG, Traore AN, Potgieter N. 2018. Enteric pathogen co-infections in the paediatric population from rural communities in the Vhembe District, South Africa. South African Journal of Child Health.12(4):170-4.

Rikhotso MC, Kabue JP, Ledwaba SE, Traoré AN, Potgieter N. 2018. Prevalence of human bocavirus in Africa and other developing countries between 2005 and 2016: a potential emerging viral pathogen for diarrhea. Journal of Tropical Medicine.2018.

 

Contact information

Telephone: +27 46 603 8458

E-mail: ellen.ledwaba@ru.ac.za

 

Last Modified: Mon, 19 Feb 2024 08:32:38 SAST